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Diabetes and Endocrinology

Home Diabetes and Endocrinology
The prevalence of gestational diabetes mellitus has increased considerably over time in the United States

Prevalence of Gestational Diabetes Up in U.S. Since 1979

From 0.3 percent in 1979-1980 to 5.8 percent in 2008-2010, partly due to trends in BMI, race
Financial incentives may boost smoking cessation rates

More Evidence Paying Smokers to Quit May Work

But cost may be $28,000 to get one additional smoker to succeed long term
Liraglutide added to capped insulin is associated with reductions in glycated hemoglobin

Liraglutide Added to Capped Insulin Reduces Hemoglobin A1c

Liraglutide also significantly reduces mean body weight, daily insulin dose; increases quality of life
Among adults with a hospitalization

Unstable Vital Signs for About One in Five Hospital Discharges

Presence of one or more instabilities linked to increased risk-adjusted odds of death or readmission
The interaction between the organic cation transporter 1 and the serotonin reuptake transporter seems to play a role in metformin intolerance

OCT1, SERT Genes Play Role in Metformin Intolerance

Intolerance up with low-expressing SERT S* alleles; multiplicative interaction for OCT1, SERT genotypes
The interaction between grapefruit juice and midazolam varies based on grapefruit juice-related characteristics such as the amount of furanocoumarin

Grapefruit-Midazolam Interaction Varies With Juice Characteristics

Grapefruit juice-drug interaction varies based on amount of furanocoumarin constituents in juice
Use of topical iodine can cause overestimation of blood glucose readings

Topical Iodine Can Cause Overestimation of Blood Glucose

Case report: 28-year-old pregnant woman with variable glucometer readings after topical iodine use
Twenty-four weeks of empagliflozin + metformin correlates with a significantly greater reduction in hemoglobin A1c compared with once-daily empagliflozin or twice-daily metformin

Greater Drop in Hemoglobin A1c With Empagliflozin + Metformin

Greater reductions in HbA1c, weight compared to empagliflozin or metformin alone
Inhibiting the sympathetic nervous system by renal denervation improves insulin sensitivity in obese canines

Renal Denervation Ups Insulin Sensitivity in Preclinical Model

Bilateral renal denervation completely normalizes hepatic insulin sensitivity in obese canines
A culturally-tailored stepwise diabetes prevention program can reduce incidence of diabetes among overweight/obese Asian Indian adults

Stepwise Program Can Reduce Diabetes Incidence

Culturally-tailored program lowers diabetes incidence in Asian Indian adults with IGT, IFG, or both