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Diabetes and Endocrinology

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Text Message Interventions May Help With Weight Management

Interventions classified as effective were more likely to last longer than 12 weeks
The reduction in risk of cardiovascular death with empagliflozin is most mediated by changes in hematocrit and hemoglobin

Plasma Volume Changes May Mediate Effects of Empagliflozin

Findings suggest reduced CV mortality risk mediated by effects on markers of plasma volume
Compared to placebo

Pioglitazone Associated With Lower Blood Leptin in Diabetes

In T2DM, leptin levels are lower with pioglitazone than placebo but not oral antidiabetic drugs
From 2015 to 2016

CDC: 2015 to 2016 Saw Drop in Life Expectancy in United States

Increase in rate of age-adjusted drug overdose deaths observed during same time period
Established bone fragility variants are associated with a concordant phenotypic model of the pediatric skeleton but not with discordant phenotypic models

Bone Fragility Variants Linked to Concordant Pediatric Skeleton

Novel loci identified for discordant multi-dimensional skeletal phenotypes
For healthy adults and individuals with well-controlled type 2 diabetes

DPP-4 Inhibitor Has Dissociated Effects on β-Cell Function

Single dose of sitagliptin linked to increases in standardized insulin secretion, active GIP, GLP-1
Intensive blood pressure lowering may similarly decrease cardiovascular events in both patients with and patients without type 2 diabetes mellitus

Intensive BP Goals Reduce Risk of Cardiovascular Events

Benefits similar in patients with and without type 2 diabetes
For patients with type 2 diabetes mellitus undergoing non-cardiac surgery

Pre-Op Liraglutide Cuts Post-Op Plasma Glucose in T2DM

Preoperative administration of liraglutide linked to lower post-op glucose, increase in pre-op nausea
Children born to mothers with rheumatoid arthritis may have an increased risk of rheumatoid arthritis

RA Exposure In Utero Tied to Increased Disease Risk

Children exposed to maternal rheumatoid arthritis have higher risk of thyroid disease, epilepsy, RA
The Centers for Medicare & Medicaid Services has released the Clinical Laboratory Fee Schedule

Payment for Laboratory Tests Set to Reduce Starting Jan. 1, 2018

CMS Clinical Laboratory Fee Schedule to result in drop in payments for physician office-based tests