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Monthly Archives: June 2018

The U.S. Food and Drug Administration has approved Epidiolex oral solution for treatment of seizures associated with Lennox-Gastaut syndrome and Dravet syndrome for patients age 2 years and older.

FDA Approves Epidiolex for Severe Forms of Epilepsy

Cannabidiol oral solution approved for patients 2 and older with Lennox-Gastaut and Dravet syndromes
A radiomic low-dose computed tomography-based approach is promising for indeterminate screen-detected nodule characterization

Radiomic Model Approach for Characterizing Nodules Promising

Eight quantitative radiologic features result in optimism-corrected area under curve of 0.939
All expectant families should have a pediatric prenatal visit

Prenatal Pediatric Visit Recommended for Expectant Families

Visit provides unique opportunity to address relationship between family and pediatric practice
Midlife fitness is associated with reduced risk of depression in later life and with reductions in the risk of cardiovascular disease (CVD) mortality and CVD mortality after later-life depression

Midlife Fitness Linked to Lower Risk of Depression, CVD Death

Reduction also seen in CVD mortality with antecedent depression in association with high fitness level
Greater reproducibility and higher concordance are seen for melanoma staging with the American Joint Committee on Cancer (AJCC) classification of cancer staging

New Guidelines Increase Melanoma Staging Reproducibility

Greater reproducibility and higher concordance for melanoma staging with implementation of AJCC 8
Genetic risk and lifestyle are independent predictors of incident cardiovascular disease and diabetes

Genetic Risk, Lifestyle Predict CVD, Diabetes Independently

No interactions seen for any outcome; log-additive effect on risk of developing cardiovascular disease
Enzalutamide treatment can significantly lower risk of metastasis or death in men with rapidly advancing

Enzalutamide Improves Outcomes for Aggressive Prostate Cancer

Treatment led to 71 percent lower risk of metastasis or death compared to placebo
Health care communication technology is a determinant of patient satisfaction in younger patients

Health Care Technology Impacts Younger Patient Satisfaction

Younger health care consumers are dissatisfied with technology capability of health care organizations
The U.S. Preventive Services Task Force recommends screening for osteoporosis to prevent fractures for women aged ≥65 years and for postmenopausal women aged <65 years at increased risk of osteoporosis. These findings form the basis of a final recommendation statement published online June 26 in the Journal of the American Medical Association.

USPSTF Favors Osteoporosis Screening to Prevent Fracture

Screening with bone measurement recommended for women aged ≥65, younger women at risk
Compared to treatment with an inhaled glucocorticoid alone

Combination of LABA + Inhaled Glucocorticoid Safe in Asthma

Also results in significantly fewer asthma exacerbations than inhaled glucocorticoid alone