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Monthly Archives: March 2016

Baricitinib

Baricitinib Superior to Placebo in Refractory Rheumatoid Arthritis

Findings based on patients with previous inadequate response to biologics
Oral estradiol therapy is associated with less progression of subclinical atherosclerosis in postmenopausal women when therapy is initiated early in menopause

Early Menopause Estradiol Tx Cuts Atherosclerosis Advance

Positive effect seen only on carotid-artery intima-media thickness
Use of nonoperative management of rectal cancer is increasing

Non-Surgical Management of Rectal Cancer Increasing

But, findings show use more likely in black, uninsured, and Medicaid patients
Omalizumab is effective in patients with moderate-to-severe chronic spontaneous urticaria symptoms and angioedema unresponsive to high doses of antihistamine treatment

Omalizumab Effective for Chronic Spontaneous Urticaria

Treatment improves quality of life, cuts angioedema recurrence
A long-acting formulation of the integrase inhibitor raltegravir can protect humanized bone marrow-liver-thymus mice from high-dose vaginal HIV challenges

Long-Acting Raltegravir Shows Promise in Protection from HIV

Long-acting formulation protects humanized mice from repeated high-dose vaginal HIV challenges
Defitelio (defibrotide sodium) has been approved by the U.S. Food and Drug Administration to treat a rare

FDA Approves First Tx for Disease Linked to Stem Cell Transplant

Hepatic veno-occlusive disease is rare, but fatal
The candidate viral entry receptor for Zika virus

Entry Receptor for Zika Virus Identified in Brain, Retina

AXL highly expressed by human radial glia, brain capillaries, and microglia in developing human cortex
Intracoronary delivery of adenovirus 5 encoding adenylyl cyclase 6 is safe for patients with heart failure and reduced ejection fraction

Gene Transfer Explored As Way to Up LV Function in Heart Failure

AC6 gene transfer increased left ventricular function through a single administration
Extended-release naltrexone is associated with a lower rate of opioid relapse than usual treatment among criminal justice offenders

Naltrexone ER Injection Cuts Opioid Relapse Rate in Inmates

Lower rate of relapse compared with usual treatment in trial involving criminal justice offenders
Longer-term antibiotic treatment does not improve health-related quality of life compared with shorter-term treatment among patients with persistent symptoms attributed to Lyme disease

No Benefit for Longer-Term Antibiotic Tx in Lyme Disease

Longer-term antibiotic tx doesn't have additional beneficial effect on health-related quality of life